RETHINC (REdefining THerapy IN early COPD) was a clinical trial to determine if individuals with early signs of Chronic Obstructive Pulmonary Disease (COPD) benefits from a long-acting bronchodilator medicine (indacaterol/glycopyrrolate). Many people with COPD have evidence of airflow obstruction on a special breathing test called spirometry; however, a subset of people with COPD do not demonstrate airflow obstruction, but have symptoms such as chronic cough and shortness of breath. RETHINC studied whether current and former smokers who do not have evidence of airflow obstruction on spirometry benefit from long-acting bronchodilators. RETHINC was sponsored by the National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH). The RETHINC study has been completed.